I am grateful for your work. Indeed benzodiazepines are highly prescribed to treat anxiety disorder. However, benzodiazepines have a higher efficacy when used for the short term. Indeed, the benefits for benzodiazepines decreased over time, whereas the risk for dependency is high. As a result, benzodiazepines are no longer recommended as the first-line treatment in Generalized Anxiety Disorder. However, these classes of drugs can be used adjunctively (Stahl & Muntner, 2019). The primary symptoms of anxiety spectrum disorder include worry or fear. Indeed these symptoms are modulated by the amygdala-centered circuit and by the cortical-striato-thalamo-cortical (CSTC) feedback loop circuit. Usually, GABA is the principal neurotransmitter involved in anxiety and the anxiolytic drug used to treat GAD.
Usually, the GABA neurotransmitter is the primary inhibitor that plays a unique role in reducing the activity of the neurons found in the amygdala and the CSTC loop. The use of benzodiazepines indeed increases its action to alleviate anxiety (Stahl & Muntner, 2019). The goal for treating patients with GAD is to realize complete remission of symptoms and prevent future relapse. Benzodiazepines are used as adjuncts in the treatment of many anxiety disorders. For example, for a patient using SSRIs or SNRIs, benzodiazepines are combined to curb the patient’s symptoms. Additionally, benzodiazepines can be used to increase the quality of life by treating panic attacks and insomnia.
Stahl, S., & Muntner, N. (2019). Stahl’s essential psychopharmacology. Cambridge University Press.
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