Classification of ADRs
ADRs Typology Debate
Various ventures have been formulated to classify ADRs through etiological characteristics in the clinical and pharmacological context. Moreover, other categories such as H and G have been developed to capture hypersensitive and genomic reactions for reported non-immunological and immunological ADRs (Shehab et al. 2016). Smyth et al. (2012) castigated the dominant ADR typology. They denoted that delineating methodology used for identifying dose and non-dose ADRs relations was erroneous because the entire cases are dose-related. Smyth et al. (2012) proposed an alternative system consisting of three primary parameters, susceptibility, time-related, and doses related factors, as the most suitable approach for categorizing ADRs. The parameters were more effective in capturing ADRs even though the newly developed categories only re-framed the traditional typologies. For instance, types G and H are susceptibility-related, types A, B, and F are related in dose, while types C, D, and E are related in time.
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